Ca2 + -Mg2 + -ATPase (ie, calcium pump) is a protease present in the membrane of tissue cells and organelles, because its ion operation is done by means of pump-like mechanism, which is called medicine For "pump". Sodium pumps and calcium pumps play a very important role in the human body, the size of their vitality is a variety of cell energy metabolism and function of an important indicator of whether the damage. Disorders in calcium pumps can lead to the development of many diseases. Studies have shown that the process of human disease and aging is due to a variety of reasons caused by the body "calcium pump" disorders, causing intracellular calcium content increased, intracellular and extracellular calcium concentration difference formed. Somebody called this process of decreasing the gradient of calcium transmembrane distribution in the human body as the "slow death of the body" process. The Ca2 + pump is located on the plasma membrane of plant cells, the mitochondrial inner membrane, the SER-like organelle, and the muscular cell sarcoplasmic reticulum of animals. It is a transmembrane protein formed by a polypeptide chain of 1000 amino acids, It is a Ca2 + -activated ATPase, which hydrolyzes one ATP to transport two Ca2 + ions to the outside of the cell to form a calcium ion gradient, usually with a very low cytosolic free Ca2 + concentration of about 10-7-10-8 mol / L, an intracellular Ca2 + concentration High, about 5 × 10-3 mol / L. Extracellular Ca2 + even a small influx into the cytoplasm will cause a significant change in cytosolic free Ca2 + concentration, resulting in a series of physiological reactions.Calcium flow can quickly extracellular signal Ca2 + is a very important signal substance.Microcellular lumen, sarcoplasmic reticulum, endoplasmic reticulum cysts contain high concentrations of Ca2 +, the concentration of more than 10-5 mol / liter, called "calcium Library. "Ca2 + is released from the calcium pool to the cytoplasm under the action of certain signals and regulates many physiological functions such as cell movement, muscle contraction, growth and differentiation.