Propyl gallate chemical called propyl gallate (propylgallate, PG), with anti-platelet aggregation, anti-thrombosis and other effects, the clinical treatment of cerebral thrombosis and other thrombotic diseases, coronary heart disease and paroxysmal dysmenorrhea have a certain effect The Because of its poor water solubility, in the preparation of injections must be added to the organic solvent propylene glycol for solubilization, the body has some adverse reactions.
Cyclodextrin inclusion as an effective solubilizing agent has been used for the preparation of a variety of pharmaceutical preparations for injection. Hydroxypropyl-β-cyclodextrin (HP-β-CD) is β-cyclodextrin Derivatives, the water solubility is better than β-cyclodextrin, and has no metabolism in the body, hemolytic and local irritation, mild adverse reactions and many other advantages.
Recently, there has been studied the preparation of propyl propionate hydroxypropyl-β-cyclodextrin inclusion complex. The results show that the preparation process of hydroxypropyl betroturin inclusion compound is simple, the inclusion rate is high, the solubility and the melting rate are improved greatly, which is of reference significance for the development of the pharmaceutical dosage form.
Cyclodextrin inclusion as an effective solubilizing agent has been used for the preparation of a variety of pharmaceutical preparations for injection. Hydroxypropyl-β-cyclodextrin (HP-β-CD) is β-cyclodextrin Derivatives, the water solubility is better than β-cyclodextrin, and has no metabolism in the body, hemolytic and local irritation, mild adverse reactions and many other advantages.
Recently, there has been studied the preparation of propyl propionate hydroxypropyl-β-cyclodextrin inclusion complex. The results show that the preparation process of hydroxypropyl betroturin inclusion compound is simple, the inclusion rate is high, the solubility and the melting rate are improved greatly, which is of reference significance for the development of the pharmaceutical dosage form.